Diabetes type 1, 2 and...5? Diabetes could be 5 separate diseases

Diabetes type 1, 2 and...5? Diabetes could be 5 separate diseases

Diabetes type 1, 2 and...5? Diabetes could be 5 separate diseases

One explanation, they say, is that diabetes diagnosis is based on only one measurement-how the body metabolizes glucose-when the disease is actually much more complex, and much more individual.

Critics of the research point out that the study was only of Scandinavians and does not take into account increased risk among populations in South Asia, where they are twice as likely to develop diabetes compared with people from white European backgrounds.

The organisation's south west regional head, Annika Palmer, said: "Both Type 1 and Type 2 diabetes are serious conditions that can lead to devastating complications such as amputation, blindness, kidney disease, stroke and heart disease if people don't receive the right care".

Patients in the fourth group were also often overweight, but their bodies weren't resistant to insulin, and they had milder symptoms and a healthier metabolism. With type 2, little insulin is produced, or does not trigger glucose uptake in the cells of the body and can be linked to obesity. So far, medical researchers only knew of type 1 and type 2 diabetes, and the findings may usher in a change in how the disease is treated.

Dr Victoria Salem, an advisor and clinical researcher at Imperial College London, said most pros realized that type 1 and type 2 was "not a horribly exact characterization framework".

The first results of ANDIS - a study covering all newly diagnosed diabetics in southern Sweden-can be seen now.

Still, the findings seem to be a positive step toward improved treatment of diabetes, which affects more than 420 million people worldwide.

The growing concern of type-2 diabetes needs no introduction - so, identifying a drug that is already in circulation that might help to fight the condition would be a welcome discovery.

While type 1 diabetes is generally diagnosed in childhood and caused by the body not producing enough insulin, type 2 occurs when the body can not produce enough insulin to meet increased demand imposed by obesity and insulin resistance (dearth of hormone receptors), and typically occurs later in life.

"This is the first step towards personalised treatment of diabetes", says Leif Groop, physician and professor of diabetes and endocrinology at Lund University in Sweden.

It's also possible that researchers will find that diabetes, specifically the subtypes that would fall into type 2 diabetes, can be classified into many more clusters than just five. People with this type do not respond to insulin and have a high likelihood of developing liver and diabetic kidney disease.

"Meanwhile, there are many drugs available for controlling blood sugar levels". These clusters can also understand the disease mechanism better they write adding that they used the key parameters that are used to monitor diabetes. This group had the largest proportion of patients prescribed insulin (42%), as well as the shortest time to insulin use (HR 26.87 versus cluster 5, 95% CI 21.17-34.11). The authors speculated that these patients would benefit most from Metformin.

"Current diagnostics and classification of diabetes are insufficient and unable to predict future complications or choice of treatment", explained Groop, who initiated the study. "Anyone with Type 2 diabetes concerned about medication should speak to a health professional".

Each cluster has different risks associated with it, and patients could respond better to different treatments, researchers say.

Severe autoimmune diabetes (SAID): this tended to start at a younger age, in people with a relatively low BMI, poor blood sugar control, insulin deficiency and GADA. And two other clusters, Mild Age-Related Diabetes (MARD) and Mild Obesity-Related Diabetes (MOD) seemed to be more benign forms of diabetes.

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