Valtrex (generic name: Valacyclovir). Information for consumers.

What is Valtrex?

Valtrex is antiviral for systemic use. The active ingredient is valacyclovir. Following oral administration is quickly and almost completely metabolized to aciclovir (and valine). Acyclovir is an antiviral drug. Effective against viruses: herpes simplex type 1 and 2, varicella zoster, cytomegalovirus, Epstein-Barr and human herpes virus type 6. In infected cells, with the participation of the viral enzymes, acyclovir is converted to a nucleotide analogue of the molecule, chemical compound necessary for nucleic acid synthesis. Chemical similarity makes it as acyclovir modified nucleotide is replaced by the appropriate virus, disrupting the synthesis of viral DNA. Consequently, the multiplication of viruses is inhibited. After oral administration valaciclovir is well absorbed from the gastrointestinal tract. The bioavailability of Acyclovir received valaciclovir is several times higher than after oral administration of acyclovir. In patients with impaired renal excretion of acyclovir is slower and the duration of its biological half-life is significantly longer. Acyclovir passes into breast milk.

When to use Valtrex?

The drug is indicated for:


Unfortunately, even if there are indications for use of the drug, you can not always use it. You can not use the product if you are allergic (hypersensitivity) to any of the ingredients or to acyclovir.

Dosaging and Administration

The product is a coated tablet. It is intended for oral use. Use the drug according to the doctor. Do not exceed the recommended dose because it does not increase the efficacy of the drug and can harm your health and life. If you have any questions concerning the drug, consult your physician. In certain specific groups of patients need additional dosage adjustment.

Infections caused by the virus varicella zoster in adults (herpes zoster and ophthalmic zoster): 1 g 3 times daily for 7 days (in adults immunocompromised additional 2 days after transformation to changes in scabs). Treatment should be initiated as soon as possible after diagnosis. There are no data regarding the effectiveness if you start receiving treatment later than 72 hours after onset of symptoms (rash, herpes zoster).

Infections caused by herpes simplex virus in adults and adolescents 12 year old immunocompetent: 500 mg two times a day. The headland herpes treatment usually lasts 3-5 days. The primary infections severe, your doctor may prescribe a drug for a longer period, up to 10 days. Dosing should begin as soon as possible after diagnosis. Herpes labialis: 2 g 2 times a day for one day (the interval between the adoption of doses should be about 12 hours, not less than 6 hours). Treatment should be initiated at the time of the earliest appearance of symptoms (tingling, burning, itching).

Immunocompromised adults: 1 g 2 times a day for at least 5 days. The primary infections severe, your doctor may prescribe a drug for a longer period, up to 10 days. Treatment should be initiated as soon as possible after diagnosis. Preventing the recurrence of infections caused by herpes simplex virus infection in adults and adolescents 12 year old immunocompetent: 500 mg 1 time per day or 250 mg two times a day. The dosage of 250 mg two times a day may be effective especially in patients with frequent recurrences of infection (more than 10 infections per year).

Immunocompromised Adults: 500 mg 2 times a day. Prevention of infections caused by cytomegalovirus and disease caused by this virus in adults and adolescents 12 age: 2 g 4 times a day, usually for 90 days (sometimes longer). Administration should start as soon as possible after organ transplantation.

There are no data on safety and efficacy in children under 12 years of age.

In elderly doctor will consider the possibility of renal impairment and, if necessary, adjust the dose. Maintain proper hydration status.

In patients with impaired renal function, it is necessary to adapt the dosage by the doctor according to the creatinine clearance. Use caution and maintain a state of proper hydration.

In patients undergoing hemodialysis, your doctor will prescribe the appropriate dosage regimen.

Due to lack of clinical experience to use doses greater than 4 g per day in patients with impaired hepatic function or liver transplant requires caution.

Valtrex during pregnancy and breastfeeding

During pregnancy, do not use any medication without consulting your doctor!

It is important that before taking any medicine during pregnancy or breast-feeding consult with your doctor and clarify beyond doubt the potential risks and benefits associated with the use of the drug. If you are pregnant or plan to become pregnant, inform your doctor prescribing a prescription for this drug.

Avoid the use of the product during pregnancy unless your doctor considers it absolutely necessary, and in its assessment of the expected benefit to the mother outweighs the potential risk to the fetus. Only a doctor can assess the risk-benefit ratio in your case. Acyclovir (the main metabolite of valaciclovir) is excreted in the milk of lactating women. Before using the product during breast-feeding, consult your doctor

Side Effects

Like all medicines, Valtrex can cause side effects, although they do not occur in all patients using this drug. Remember that the expected benefits of the drug are usually larger than the damage resulting from the emergence of side effects.

The most common are: headache, dizziness, nausea, vomiting, diarrhea, rash, photosensitivity, pruritus. Uncommon: abnormal hematologic (thrombocytopenia, a decrease in white blood cells, particularly in immunocompromised persons), confusion, hallucinations, confusion, tremor, agitation, shortness of breath, abdominal pain, increased liver enzymes, increased bilirubin, renal pain (may be associated with renal failure), haematuria.

Rare: ataxia, slurred speech, coma, encephalopathy, psychotic symptoms, seizures, delirium (in patients receiving high dose, for example, in the prevention of CMV infection side effects on the nervous system are much more common than during the administration of lower doses for other indications) , renal dysfunction, acute renal failure (especially in the elderly or with impaired renal function receiving high dose), angioneurotic edema and anaphylactic reactions.


The benefits of Valtrex

Valtrex relieves the symptoms of herpes zoster and genital herpes within 24 hours of taking the first dose. The drug also effectively prevents the spread of the virus, allowing the body to self eradicate the infection. As a result, the patient's recovery is faster, and the symptoms associated with the disease are much less annoying and painful.

Those wishing to fight the outbreak of herpes or prevent its occurrence can securely purchase antiviral drugs via the Internet. Our clinic site for 10 years now, is a safe alternative for all, which is hard to take the traditional visit to the doctor. To place an order please complete the form online consultation, which will be forwarded for evaluation to one of our doctors. If the drug proves to be competent for the authority by persons, the doctor will issue a prescription which will be communicated to our pharmacy, and then sent to the recipient courier service. Delivery is free and takes 24 - 48 hours.

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